Tg(Defa2-Myd88)1Lvh
Transgene Detail

Summary

• Symbol: Tg(Defa2-Myd88)1Lvh
• Name: transgene insertion 1, Lora Hooper
• MGI ID: MGI:4941629
• Synonyms: Cr2-FlagMyd88
• Transgene: Tg(Defa2-Myd88)1Lvh Location: unknown
• Alliance: Tg(Defa2-Myd88)1Lvh page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Defa2-Myd88)1Lvh expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Myd88 (MGI:108005)

• Mutation details: FLAG-tagged Myd88 was placed under the transcriptional control of nucleotides -6500 to +134 of the mouse Defa2 (defensin, alpha, 2; also known as cryptdin 2) gene. Human growth hormone (hGH, +3 to +2150) was placed immediately downstream to enhance transgenic expression, but is not transcribed. (J:169662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:169662 Vaishnava S, et al., Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20858-63
• All: 1 reference(s)