Tg(ML4sHEL)4Ccg
Transgene Detail

Summary

• Symbol: Tg(ML4sHEL)4Ccg
• Name: transgene insertion 4, Christopher C Goodnow
• MGI ID: MGI:4889214
• Synonyms: ML4, Tg(ML4sHEL)5Ccg
• Transgene: Tg(ML4sHEL)4Ccg Location: unknown
• Alliance: Tg(ML4sHEL)4Ccg page

Transgene origin

• Strain of Origin: C57BL/6JSfd

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: This transgene contains the coding exons of the chicken lysozyme gene downstream of the mouse metallothionein I (Mt1) promoter. Mice of this transgenic line constitutively express very little hen egg lysozyme, exhibiting very low concentrations in serum (>5 ng/ml). However, zinc induction of the promoter (by supplementing the drinking water with zinc sulfate (25mM) for >= 5 days) raises the serum HEL concentration to ~200 ng/ml. (J:78308, J:127344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:78308 Goodnow CC, et al., Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature. 1988 Aug 25;334(6184):676-82
• All: 3 reference(s)