Tg(Lck-cre)19Hhan
Transgene Detail

Summary

• Symbol: Tg(Lck-cre)19Hhan
• Name: transgene insertion 19, Hua Han
• MGI ID: MGI:4889049
• Synonyms: LckCre, Lck-Cre
• Transgene: Tg(Lck-cre)19Hhan Location: unknown
• Alliance: Tg(Lck-cre)19Hhan page

Transgene origin

• Strain of Origin: (DBA x C57BL/6)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Lck-cre)19Hhan expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Lck

• Mutation details: The cre recombinase sequence was fused to a nuclear localization signal and inserted between the Lck promoter and the 3' untranslated fragment of the human beta-globin gene in the transgene. The construct was microinjected into male pronuclei of fertilized oocytes. Animals from 2 lines (19,20) were crossed mice carrying a floxed RBP-J allele to determine the activity of the cre transgene. Southern blot analysis of thymocytes from line #19 animals heterozygous for Rbpj^tm1Hon showed complete deletion of the floxed locus. (J:168475)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Lck (species not specified) Summary of all recombinase alleles driven by Lck.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:168475 Fu T, et al., Accelerated acute allograft rejection accompanied by enhanced T-cell proliferation and attenuated Treg function in RBP-J deficient mice. Mol Immunol. 2011 Feb;48(5):751-9
• All: 3 reference(s)