Mylk3tm1Jtst
Targeted Allele Detail
|
Symbol: |
Mylk3tm1Jtst |
Name: |
myosin light chain kinase 3; targeted mutation 1, James Stull |
MGI ID: |
MGI:4881762 |
Synonyms: |
cMLCKneo |
Gene: |
Mylk3 Location: Chr8:86050933-86112969 bp, - strand Genetic Position: Chr8, 41.61 cM
|
Alliance: |
Mylk3tm1Jtst page
|
|
Mylk3tm1Jtst/Mylk3+ and Mylk3tm1Jtst/Mylk3tm1Jtst mice exhibit hypertrophic hearts
Show the 1 phenotype image(s) involving this allele.
|
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:167590
|
Parent Cell Line: |
Not Specified (ES Cell)
|
Strain of Origin: |
129S/SvEv
|
|
Allele Type: |
|
Targeted (Null/knockout) |
Mutation: |
|
Insertion
|
|
|
Mutation details: A loxP site was inserted upstream of exon 4, and an FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. The absence of protein expression was confirmed by western blot analysis on ventricular and atrial extracts.
(J:167590)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
Carrying any Mylk3 Mutation: |
42 strains or lines available
|
|
Original: |
J:167590 Ding P, et al., Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo. J Biol Chem. 2010 Dec 24;285(52):40819-29 |
All: |
1 reference(s) |
|