Tg(Scgb1a1-iDab#6-memb)#Thr
Transgene Detail

Summary

• Symbol: Tg(Scgb1a1-iDab#6-memb)#Thr
• Name: transgene insertion, Terence H Rabbitts
• MGI ID: MGI:4880870
• Synonyms: CC10-iDab#6-memb
• Transgene: Tg(Scgb1a1-iDab#6-memb)#Thr Location: unknown
• Alliance: Tg(Scgb1a1-iDab#6-memb)#Thr page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A transgene expressing a single immunoglobulin heavy chain variable domain fragment (designated intracellular Domain antibody iDab#6-memb) that specifically binds to the activated form of RAS (GTP-bound RAS) The single domain binds with high affinity and specificity to the RAS switch I region and interferes with oncogenic RAS function inside the cell by competitively preventing RAS-effector interactions. Line numbers of founder animals were not specified. (J:167647)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Scgb1a1-iDab#6-memb)#Thr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:167647 Tanaka T, et al., Interfering with RAS-effector protein interactions prevent RAS-dependent tumour initiation and causes stop-start control of cancer growth. Oncogene. 2010 Nov 11;29(45):6064-70
• All: 1 reference(s)