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Spdeftm1Shiv
Targeted Allele Detail
Summary
Symbol: Spdeftm1Shiv
Name: SAM pointed domain containing ets transcription factor; targeted mutation 1, Ramesh Shivdasani
MGI ID: MGI:4867866
Gene: Spdef  Location: Chr17:27933326-27947929 bp, - strand  Genetic Position: Chr17, 14.59 cM, cytoband B1
Alliance: Spdeftm1Shiv page
Polypoid antral hyperplasia in Spdeftm1Shiv/Spdeftm1Shiv mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166876
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-5 were replaced with a PGK-neomycin resistance cassette. This removed the transactivation domain, the Pointed domain, and most of the Ets DNA binding domain. Absence of protein was confirmed by immunostaining. (J:166876)
Generation of the Spdeftm1Shiv allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spdef Mutation:  15 strains or lines available
References
Original:  J:166876 Horst D, et al., Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum. J Biol Chem. 2010 Nov 5;285(45):35047-55
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory