Prkd1^tm1.1Daca
Targeted Allele Detail

Summary

• Symbol: Prkd1^tm1.1Daca
• Name: protein kinase D1; targeted mutation 1.1, Doreen A Cantrell
• MGI ID: MGI:4867731
• Synonyms: PKD1(S744A/S748A), Prkd1^SSAA
• Gene: Prkd1 Location: Chr12:50388014-50695881 bp, - strand Genetic Position: Chr12, 21.78 cM, cytoband C1
• Alliance: Prkd1^tm1.1Daca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166867
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 17 was replaced with a modified one in which nucleotide substitution results in the amino acid substitution of alanine for serine at positions 744 and 748 (S744A, S748A). A floxed neo cassette inserted downstream of the modified exon 17 was removed by cre-mediated recombination. (J:166867)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkd1 Mutation: 58 strains or lines available

References

• Original: J:166867 Matthews SA, et al., Unique functions for protein kinase D1 and protein kinase D2 in mammalian cells. Biochem J. 2010 Oct 25;432(1):153-63
• All: 3 reference(s)