Naca^tm1Dsr
Targeted Allele Detail

Summary

• Symbol: Naca^tm1Dsr
• Name: nascent polypeptide-associated complex alpha polypeptide; targeted mutation 1, Deepak Srivastava
• MGI ID: MGI:4867685
• Synonyms: skNAC^null
• Gene: Naca Location: Chr10:127871444-127884506 bp, + strand Genetic Position: Chr10, 76.39 cM, cytoband D2-D3
• Alliance: Naca^tm1Dsr page

Cardiomyocyte defect in Naca^tm1Dsr/Naca^tm1Dsr embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:167169
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The muscle restricted isoform specific exon 2 was replaced with an FRT flanked neo cassette via homologous recombination. RT-PCR analysis confirmed the absence of expression of the muscle specific isoform and presence of expression of the other isoform. (J:167169)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Naca Mutation: 70 strains or lines available

References

• Original: J:167169 Park CY, et al., skNAC, a Smyd1-interacting transcription factor, is involved in cardiac development and skeletal muscle growth and regeneration. Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20750-5
• All: 1 reference(s)