About   Help   FAQ
Targeted Allele Detail
Symbol: Gba1tm1.1Pmis
Name: glucosylceramidase beta 1; targeted mutation 1.1, Pramod K Mistry
MGI ID: MGI:4867659
Synonyms: GBA1LoxP
Gene: Gba1  Location: Chr3:89110235-89116273 bp, + strand  Genetic Position: Chr3, 39.01 cM
Alliance: Gba1tm1.1Pmis page
Germline Transmission:  Earliest citation of germline transmission: J:167081
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed neo cassette was inserted upstream of exon 8 and an additional loxP site was inserted downstream of exon 11. Cre-mediated recombination removed the neo cassette leaving exons 8 through 11 floxed. (J:167081)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gba1 Mutation:  43 strains or lines available
Original:  J:167081 Mistry PK, et al., Glucocerebrosidase gene-deficient mouse recapitulates Gaucher disease displaying cellular and molecular dysregulation beyond the macrophage. Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19473-8
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.13
The Jackson Laboratory