Sox9^{tm1(cre/ERT2)Haak}
Targeted Allele Detail

Summary

• Symbol: Sox9^{tm1(cre/ERT2)Haak}
• Name: SRY (sex determining region Y)-box 9; targeted mutation 1, Haruhiko Akiyama
• MGI ID: MGI:4867441
• Synonyms: Sox9^CreERT2, Sox9^IRES-CreERT2
• Gene: Sox9 Location: Chr11:112673050-112678586 bp, + strand Genetic Position: Chr11, 77.27 cM
• Alliance: Sox9^{tm1(cre/ERT2)Haak} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166624
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Sox9^{tm1(cre/ERT2)Haak} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sox9 (MGI:98371)

• Mutation details: A targeting cassette containing IRES-cre/ERT2-pA and FRT-flanked PGK-neo-bpA sequences was introduced into AB1 ES cells. Homologous recombination inserted into the 3' UTR of exon 3 of the Sox9 locus. Targeted ES cells were injected into C57BL/6 blastocysts to produce chimeras which were crossed with C57BL/6 wild-type animals. The neo cassette was not removed from the targeted allele. (J:166624)

Generation of the Sox9^{tm1(cre/ERT2)Haak} allele

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sox9 (mouse) Summary of all recombinase alleles driven by Sox9. Alliance mouse Sox9 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox9 Mutation: 32 strains or lines available

References

• Original: J:166624 Soeda T, et al., Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis. 2010 Nov;48(11):635-44
• All: 57 reference(s)