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Sox9tm1(cre/ERT2)Haak
Targeted Allele Detail
Summary
Symbol: Sox9tm1(cre/ERT2)Haak
Name: SRY (sex determining region Y)-box 9; targeted mutation 1, Haruhiko Akiyama
MGI ID: MGI:4867441
Synonyms: Sox9CreERT2, Sox9IRES-CreERT2
Gene: Sox9  Location: Chr11:112673050-112678586 bp, + strand  Genetic Position: Chr11, 77.27 cM
Alliance: Sox9tm1(cre/ERT2)Haak page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:166624
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Sox9tm1(cre/ERT2)Haak expression driven by 1 gene
 
Mutation detailsA targeting cassette containing IRES-cre/ERT2-pA and FRT-flanked PGK-neo-bpA sequences was introduced into AB1 ES cells. Homologous recombination inserted into the 3' UTR of exon 3 of the Sox9 locus. Targeted ES cells were injected into C57BL/6 blastocysts to produce chimeras which were crossed with C57BL/6 wild-type animals. The neo cassette was not removed from the targeted allele. (J:166624)
Generation of the Sox9tm1(cre/ERT2)Haak allele
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sox9 (mouse)
Summary of all recombinase alleles driven by Sox9.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox9 Mutation:  32 strains or lines available
References
Original:  J:166624 Soeda T, et al., Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis. 2010 Nov;48(11):635-44
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory