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Targeted Allele Detail
Symbol: Sox9tm1(cre/ERT2)Haak
Name: SRY (sex determining region Y)-box 9; targeted mutation 1, Haruhiko Akiyama
MGI ID: MGI:4867441
Synonyms: Sox9CreERT2, Sox9IRES-CreERT2
Gene: Sox9  Location: Chr11:112673050-112678586 bp, + strand  Genetic Position: Chr11, 77.27 cM
Alliance: Sox9tm1(cre/ERT2)Haak page
Germline Transmission:  Earliest citation of germline transmission: J:166624
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
Sox9tm1(cre/ERT2)Haak expression driven by 1 gene
Mutation detailsA targeting cassette containing IRES-cre/ERT2-pA and FRT-flanked PGK-neo-bpA sequences was introduced into AB1 ES cells. Homologous recombination inserted into the 3' UTR of exon 3 of the Sox9 locus. Targeted ES cells were injected into C57BL/6 blastocysts to produce chimeras which were crossed with C57BL/6 wild-type animals. The neo cassette was not removed from the targeted allele. (J:166624)
Generation of the Sox9tm1(cre/ERT2)Haak allele
 Tissue activity of this recombinase allele
Driver: Sox9 (mouse)
Summary of all recombinase alleles driven by Sox9.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sox9 Mutation:  32 strains or lines available
Original:  J:166624 Soeda T, et al., Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons. Genesis. 2010 Nov;48(11):635-44
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory