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Targeted Allele Detail
Symbol: Adcy5tm1e(KOMP)Wtsi
Name: adenylate cyclase 5; targeted mutation 1e, Wellcome Trust Sanger Institute
MGI ID: MGI:4843829
Gene: Adcy5  Location: Chr16:34975247-35126108 bp, + strand  Genetic Position: Chr16, 24.71 cM, cytoband B-5
Alliance: Adcy5tm1e(KOMP)Wtsi page
IMPC: Adcy5 gene page
Mutant Cell Lines:  EPD0494_2_A03, EPD0494_2_B02, EPD0494_2_B03, EPD0494_2_B04, EPD0494_2_C01, EPD0494_2_C02, EPD0494_2_C03, EPD0494_2_C04, EPD0494_2_D03, EPD0494_2_E01, EPD0494_2_E02, EPD0494_2_E03, EPD0494_2_E04, EPD0494_2_F03, EPD0494_2_H03, EPD0681_5_A03, EPD0681_5_B03, EPD0681_5_D03, EPD0681_5_E03, EPD0681_5_E04, EPD0681_5_F01
Germline Transmission:  Earliest citation of germline transmission: J:204812
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 35091958 of Chromosome 16 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Insertion of this cassette creates a reporter knockout mouse. Cre expression will remove the neomycin selection cassette. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:148605, J:173534)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Adcy5 Mutation:  38 strains or lines available
Original:  J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009;
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory