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Cc2d1atm1a(KOMP)Mbp
Targeted Allele Detail
Summary
Symbol: Cc2d1atm1a(KOMP)Mbp
Name: coiled-coil and C2 domain containing 1A; targeted mutation 1a, Mouse Biology Program, UC Davis
MGI ID: MGI:4840725
Gene: Cc2d1a  Location: Chr8:84859457-84874546 bp, - strand  Genetic Position: Chr8, 40.32 cM
IMPC: Cc2d1a gene page
Mutation
origin
Mutant Cell Lines:  DEPD00533_1_A06, DEPD00533_1_A08, DEPD00533_1_C06, DEPD00533_1_D07, DEPD00533_1_E08, DEPD00533_1_F06, DEPD00533_1_F07, DEPD00533_1_G06, DEPD00533_1_H06
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 84864826 of Chromosome 8 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 84866480. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Cc2d1a Mutation:  32 strains or lines available
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory