Cdh1^tm1Cle
Targeted Allele Detail

Summary

• Symbol: Cdh1^tm1Cle
• Name: cadherin 1; targeted mutation 1, Hans Clevers
• MGI ID: MGI:4838590
• Synonyms: Ecad^CFP, E-cadherin-mCFP
• Gene: Cdh1 Location: Chr8:107329983-107396878 bp, + strand Genetic Position: Chr8, 53.18 cM, cytoband D
• Alliance: Cdh1^tm1Cle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164644
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Monomeric cyan fluorescent protein (mCFP) and a loxP-flanked neomycin cassette were targeted to exon 16 (encoding the endogenous STOP codon) to maintain normal expression levels and patterns. (J:164644)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh1 Mutation: 171 strains or lines available

References

• Original: J:164644 Snippert HJ, et al., Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 2010 Oct 1;143(1):134-44
• All: 15 reference(s)