Wnt4^tm1Boer
Targeted Allele Detail

Summary

• Symbol: Wnt4^tm1Boer
• Name: wingless-type MMTV integration site family, member 4; targeted mutation 1, Derek Boerboom
• MGI ID: MGI:4838044
• Gene: Wnt4 Location: Chr4:137004946-137026812 bp, + strand Genetic Position: Chr4, 69.8 cM
• Alliance: Wnt4^tm1Boer page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162337
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxp site was inserted upstream of exon 3, and frt flanked neo cassette with a 5' loxP site was inserted downstream of exon 4. (J:162337)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wnt4 Mutation: 23 strains or lines available

References

• Original: J:162337 Boyer A, et al., WNT4 is required for normal ovarian follicle development and female fertility. FASEB J. 2010 Aug;24(8):3010-25
• All: 1 reference(s)