Hand1tm1.1(EGFP/cre)Abfi
Targeted Allele Detail
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Symbol: |
Hand1tm1.1(EGFP/cre)Abfi |
Name: |
heart and neural crest derivatives expressed 1; targeted mutation 1.1, Anthony B Firulli |
MGI ID: |
MGI:4838016 |
Synonyms: |
Hand1EGFPCredeltaNeo |
Gene: |
Hand1 Location: Chr11:57719539-57722973 bp, - strand Genetic Position: Chr11, 35.27 cM
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Alliance: |
Hand1tm1.1(EGFP/cre)Abfi page
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Germline Transmission: |
Earliest citation of germline transmission:
J:165398
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Parent Cell Line: |
CCE916 (ES Cell)
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Strain of Origin: |
129S/SvEv
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Allele Type: |
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Targeted (Recombinase) |
Mutations: |
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Insertion, Intragenic deletion
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Hand1tm1.1(EGFP/cre)Abfi expression driven by
1 gene
Knock-in expression driven by:
Organism |
Driver Gene |
Note |
mouse |
Hand1 (MGI:103577) |
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Mutation details: A targeting vector containing a 3.4 kb EGFP/cre cassette with a 3' Frt-flanked neomycin cassette was introduced into the 5' untranslated region of Hand1. Homologous recombination resulted in deletion of the first exon of Hand1, producing a null allele, and insertion of the EGFP/cre gene under control of the endogenous promoter. Following germline transmission, the neo cassette was deleted by crossing mice to FLPeR homozygous mice.
(J:165398)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Hand1
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:165398 Barnes RM, et al., Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra-embryonic, and lateral mesoderm derivatives. Dev Dyn. 2010 Nov;239(11):3086-97 |
All: |
6 reference(s) |
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