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Targeted Allele Detail
Symbol: Pkd1l3tm1.1Abek
Name: polycystic kidney disease 1 like 3; targeted mutation 1.1, Keiko Abe
MGI ID: MGI:4837113
Gene: Pkd1l3  Location: Chr8:110340828-110399305 bp, + strand  Genetic Position: Chr8, 57.14 cM, cytoband A
Alliance: Pkd1l3tm1.1Abek page
Germline Transmission:  Earliest citation of germline transmission: J:165309
Parent Cell Line:  EF1 (ES Cell)
Strain of Origin:  129S/SvEv x C57BL/6
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 26 through 31 with an IRES, an EGFP, and a self-excising floxed neo cassette. These exons encode transmembrane domains 7 through 11. In situ hybridization confirmed the absence of transcript expression in the taste buds of the circumvallate papillae. (J:165309)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pkd1l3 Mutation:  66 strains or lines available
Original:  J:165309 Ishimaru Y, et al., Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. FASEB J. 2010 Oct;24(10):4058-67
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory