Krit1^tm1Sfre
Targeted Allele Detail

Summary

• Symbol: Krit1^tm1Sfre
• Name: KRIT1, ankyrin repeat containing; targeted mutation 1, Saverio Francesco Retta
• MGI ID: MGI:4836712
• Gene: Krit1 Location: Chr5:3853156-3894515 bp, + strand Genetic Position: Chr5, 2.26 cM
• Alliance: Krit1^tm1Sfre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163084
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neo cassette replaced 631 bp of genomic sequence including 554 bp of the 5' untranslated region, the start codon, and 77 nucleotides of exon 1. The absence of protein expression was confirmed by western blot analysis on mouse embryonic fibroblasts. (J:163084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krit1 Mutation: 34 strains or lines available

References

• Original: J:163084 Goitre L, et al., KRIT1 regulates the homeostasis of intracellular reactive oxygen species. PLoS One. 2010;5(7):e11786
• All: 3 reference(s)