Prox2^tm1Aoh
Targeted Allele Detail

Summary

• Symbol: Prox2^tm1Aoh
• Name: prospero homeobox 2; targeted mutation 1, Akihira Ohtoshi
• MGI ID: MGI:4835278
• Gene: Prox2 Location: Chr12:85133159-85157533 bp, - strand Genetic Position: Chr12, 39.54 cM
• Alliance: Prox2^tm1Aoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:164796
• Parent Cell Line: PC3 (ES Cell)
• Strain of Origin: 129S4/SvJae-Tg(Prm-cre)70Og

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 4.7 kb BamHI-HindIII genomic segment containing the first coding exon was replaced by a floxed neomycin selection cassette. The translation start site and part of a homeodomain were removed. The Prm1-cre transgene present in PC3 ES cells excised the selection cassette when it was expressed in spermatids of male chimeras. (J:164796)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prox2 Mutation: 19 strains or lines available

References

• Original: J:164796 Nishijima I, et al., Characterization of a novel prospero-related homeobox gene, Prox2. Mol Genet Genomics. 2006 May;275(5):471-8
• All: 1 reference(s)