Tg(Tagln-LacZ)4Zli
Transgene Detail

Summary

• Symbol: Tg(Tagln-LacZ)4Zli
• Name: transgene insertion 4, Zhenlin Li
• MGI ID: MGI:4835063
• Synonyms: SM 22-lacZ, SM 22-nlslacZ
• Transgene: Tg(Tagln-LacZ)4Zli Location: unknown
• Alliance: Tg(Tagln-LacZ)4Zli page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The transgene contains nucleotides -2126 through +65 (the end of exon 1) of the mouse transgelin/SM 22 promoter region driving expression of E. coli beta-galactosidase with a nuclear localization signal. In transgenic embryos, beta-galactosidase expression is detected in the somites and the presumptive right ventricle and outflow tract of the heart and subsequently in the arteries, but not in the visceral muscles or veins. In adults expression is seen in arterial smooth muscle cells, but not in other smooth muscles. (J:34770)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

Three mouse lines were generated that expressed and transmitted the transgene, of which two were characterized. They are not named and no distinction is made among them in the primary reference. (J:34770)

References

• Original: J:34770 Moessler H, et al., The SM 22 promoter directs tissue-specific expression in arterial but not in venous or visceral smooth muscle cells in transgenic mice. Development. 1996 Aug;122(8):2415-25
• All: 3 reference(s)