Slc47a1^tm1Kinu
Targeted Allele Detail

Summary

• Symbol: Slc47a1^tm1Kinu
• Name: solute carrier family 47, member 1; targeted mutation 1, Ken-ichi Inui
• MGI ID: MGI:4830581
• Synonyms: Mate1^-
• Gene: Slc47a1 Location: Chr11:61234227-61269171 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Slc47a1^tm1Kinu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:163959
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on brush-border membrane extracts. (J:163959)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc47a1 Mutation: 44 strains or lines available

References

• Original: J:163959 Tsuda M, et al., Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. Mol Pharmacol. 2009 Jun;75(6):1280-6
• All: 3 reference(s)