Otulin^m3Sapc
Chemically induced Allele Detail

Summary

• Symbol: Otulin^m3Sapc
• Name: OTU deubiquitinase with linear linkage specificity; mutation 3, Sabine Cordes
• MGI ID: MGI:4830117
• Synonyms: gumby, Gum^W96R, m3Sapc, m7-1Sapc, m7-6Sapc
• Gene: Otulin Location: Chr15:27606005-27630793 bp, - strand Genetic Position: Chr15, 10.31 cM
• Alliance: Otulin^m3Sapc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutant was the result of an ENU screen. Meiotic mapping of 154 progeny from intercrossed heterozygotes refined the critical interval to 1.7 megabases (Mb) between D15Mit18 and single nucleotide polymorphism (SNP) rs13482490 on mouse chromosome 15. Gene sequencing in this interval identified a T-to-A transversion (T285A) in the third exon of the Fam105b gene, which replaced tryptophan at position 96 with arginine. (J:163657, J:197674)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Otulin Mutation: 22 strains or lines available

References

• Original: J:163657 Mar L, et al., A genetic screen for mutations that affect cranial nerve development in the mouse. J Neurosci. 2005 Dec 14;25(50):11787-95
• All: 2 reference(s)