Gprasp1^tm1.1Jlw
Targeted Allele Detail

Summary

• Symbol: Gprasp1^tm1.1Jlw
• Name: G protein-coupled receptor associated sorting protein 1; targeted mutation 1.1, Jennifer L Whistler
• MGI ID: MGI:4820816
• Gene: Gprasp1 Location: ChrX:134643482-134704223 bp, + strand Genetic Position: ChrX, 57.26 cM, cytoband F1
• Alliance: Gprasp1^tm1.1Jlw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161807
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted upstream of exon 5, and an additional loxP site was inserted downstream of exon 5. Cre mediated recombination removed exon 5 and the neo cassette. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:161807)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gprasp1 Mutation: 30 strains or lines available

References

• Original: J:161807 Thompson D, et al., Altered ratio of D1 and D2 dopamine receptors in mouse striatum is associated with behavioral sensitization to cocaine. PLoS One. 2010;5(6):e11038
• All: 3 reference(s)