Myc^{tm(Igh-V-EGFP)Janz}
Targeted Allele Detail

Summary

• Symbol: Myc^{tm(Igh-V-EGFP)Janz}
• Name: Myc proto-oncogene, bHLH transcription factor; targeted mutation 1, Siegfried Janz
• MGI ID: MGI:4818379
• Synonyms: iGFP^5'Myc
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^{tm(Igh-V-EGFP)Janz} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:162138
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The EGFP gene driven by the immunoglobulin heavy chain variable region (VH) and a floxed neo cassette were inserted 1.5 Kb upstream of the first non-coding exon. The VH-EGFP reporter gene is in the opposite orientation of Myc. This allele serves as a reporter of chromosomal T(12;15) translocation in B lymphocytes and plasma cells. (J:162138)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 42 strains or lines available

References

• Original: J:162138 Takizawa M, et al., Genetic reporter system for oncogenic Igh-Myc translocations in mice. Oncogene. 2010 Jul 15;29(28):4113-20
• All: 1 reference(s)