Igh^tm2.1Fwa
Targeted Allele Detail

Summary

• Symbol: Igh^tm2.1Fwa
• Name: immunoglobulin heavy chain complex; targeted mutation 2.1, Frederick W Alt
• MGI ID: MGI:4818343
• Synonyms: deltaSgamma1
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:161437
• Parent Cell Line: EF1 (ES Cell)
• Strain of Origin: 129S/SvEv x C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the Sgamma1 region and a floxed neo cassette was inserted downstream of the region. Cre mediated recombination removed the neo cassette and the Sgamma1 region. (J:97050)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 43 strains or lines available

References

• Original: J:161437 Misaghi S, et al., Increased targeting of donor switch region and IgE in Sgamma1-deficient B cells. J Immunol. 2010 Jul 1;185(1):166-73
• All: 2 reference(s)