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Lrrc75btm1a(KOMP)Mbp
Targeted Allele Detail
Summary
Symbol: Lrrc75btm1a(KOMP)Mbp
Name: leucine rich repeat containing 75B; targeted mutation 1a, Mouse Biology Program, UC Davis
MGI ID: MGI:4462513
Gene: Lrrc75b  Location: Chr10:75385957-75396164 bp, - strand  Genetic Position: Chr10, 38.55 cM
IMPC: Lrrc75b gene page
Mutation
origin
Mutant Cell Lines:  DEPD00526_4_B03, DEPD00526_4_C01, DEPD00526_4_C02, DEPD00526_4_C03, DEPD00526_4_D02, DEPD00526_4_D03, DEPD00526_4_D04, DEPD00526_4_E01, DEPD00526_4_E03, DEPD00526_4_E04, DEPD00526_4_F01, DEPD00526_4_F04, DEPD00526_4_G03, DEPD00526_4_H02, DEPD00526_4_H04
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Reporter)
Mutation:    Insertion     Vector: L1L2_Bact_P
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 75391467 of Chromosome 10 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 75393563. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Lrrc75b Mutation:  6 strains or lines available
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory