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Naif1tm1(KOMP)Mbp
Targeted Allele Detail
Summary
Symbol: Naif1tm1(KOMP)Mbp
Name: nuclear apoptosis inducing factor 1; targeted mutation 1, Mouse Biology Program, UC Davis
MGI ID: MGI:4462498
Gene: Naif1  Location: Chr2:32340469-32346965 bp, + strand  Genetic Position: Chr2, 22.09 cM
IMPC: Naif1 gene page
Mutation
origin
Mutant Cell Lines:  DEPD00505_3_A05, DEPD00505_3_B05, DEPD00505_3_B06, DEPD00505_3_B08, DEPD00505_3_C05, DEPD00505_3_C06, DEPD00505_3_C07, DEPD00505_3_D05, DEPD00505_3_D08, DEPD00505_3_E06, DEPD00505_3_E07, DEPD00505_3_E08, DEPD00505_3_F05, DEPD00505_3_F07, DEPD00505_3_G05, DEPD00505_3_H07
Germline Transmission:  Unknown
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
 
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 515 starting at position 32344788 and ending at position 32345303 of Chromosome 2 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 1 line available
Carrying any Naif1 Mutation:  20 strains or lines available
References
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory