Pde11a^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Pde11a^tm1Dgen
• Name: phosphodiesterase 11A; targeted mutation 1, Deltagen
• MGI ID: MGI:4462264
• Gene: Pde11a Location: Chr2:75819485-76169118 bp, - strand Genetic Position: Chr2, 44.8 cM
• Alliance: Pde11a^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160319
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A LacZ Neo cassette was inserted by homologous recombination to delete catalytic domain amino acids 693-717 (corresponding to bases 2123-2199). Deletion of mRNA in was confirmed by quantitative PCR, and deletion of protein was confirmed by Western blotting with multiple antibodies. (J:160319)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pde11a Mutation: 48 strains or lines available

References

• Original: J:160319 Kelly MP, et al., Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A. 2010 May 4;107(18):8457-62
• All: 8 reference(s)