Chrm3^tm1Abt
Targeted Allele Detail

Summary

• Symbol: Chrm3^tm1Abt
• Name: cholinergic receptor, muscarinic 3, cardiac; targeted mutation 1, Andrew B Tobin
• MGI ID: MGI:4459925
• Gene: Chrm3 Location: Chr13:9925522-10410883 bp, - strand Genetic Position: Chr13, 3.72 cM
• Alliance: Chrm3^tm1Abt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160283
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The coding region was replaced with one containing 15 point mutations that altered serine to alanine at phospho-acceptor sites within the third intracellular loop (positions 285, 286, 288, 290, 291, 302, 303, 331, 332, 333, 335, 374, 379, 384, and 385). A neo cassette was inserted downstream of the modified coding region. (J:160283)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm3 Mutation: 52 strains or lines available

References

• Original: J:160283 Poulin B, et al., The M3-muscarinic receptor regulates learning and memory in a receptor phosphorylation/arrestin-dependent manner. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9440-5
• All: 4 reference(s)