C1galt1c1^tm1.2Rdcu
Targeted Allele Detail

Summary

• Symbol: C1galt1c1^tm1.2Rdcu
• Name: C1GALT1-specific chaperone 1; targeted mutation 1.2, Richard D Cummings
• MGI ID: MGI:4459541
• Gene: C1galt1c1 Location: ChrX:37719662-37723964 bp, - strand Genetic Position: ChrX, 22.91 cM, cytoband A2
• Alliance: C1galt1c1^tm1.2Rdcu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160290
• Parent Cell Line: HZ2.2 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed the coding exon and neo cassette. The absence of transcript expression was confirmed by RT-PCR on mutant embryonic stem cells. (J:160290)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C1galt1c1 Mutation: 16 strains or lines available

References

• Original: J:160290 Wang Y, et al., Cosmc is an essential chaperone for correct protein O-glycosylation. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9228-33
• All: 1 reference(s)