Prkn^tm1Jfe
Targeted Allele Detail

Summary

• Symbol: Prkn^tm1Jfe
• Name: parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Jian Feng
• MGI ID: MGI:4456262
• Gene: Prkn Location: Chr17:11059271-12282248 bp, + strand Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
• Alliance: Prkn^tm1Jfe page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160272
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was deleted. The absence of protein expression was confirmed by western blot analysis on brain extracts. (J:160272)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkn Mutation: 55 strains or lines available

References

• Original: J:160272 Roth JA, et al., Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1. J Neurochem. 2010 Apr 1;113(2):454-64
• All: 1 reference(s)