Tg(tetO-HTLV1-Tax)1Wcg
Transgene Detail

Summary

• Symbol: Tg(tetO-HTLV1-Tax)1Wcg
• Name: transgene insertion 1, Warner Greene
• MGI ID: MGI:4456222
• Synonyms: Tet-o-Tax
• Transgene: Tg(tetO-HTLV1-Tax)1Wcg Location: unknown
• Alliance: Tg(tetO-HTLV1-Tax)1Wcg page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: This transgene contains a cDNA encoding the viral 40-kDa Tax transactivator protein of human T-lymphotropic virus, type I (HTLV-1; also called human T-cell leukemia virus, type I) under control of the Tet operon (tetO), which comprises seven copies of the tetracycline responsive element (TRE) upstream of the cytomegalovirus minimal promoter. In a bitransgenic mouse also expressing tTA (tet-off) or rtTA (tet-on) from a tissue-specific promoter, Tax is conditionally expressed in the absence or presence, respectively, of tetracycline. (J:102153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:102153 Kwon H, et al., Lethal cutaneous disease in transgenic mice conditionally expressing type I human T cell leukemia virus Tax. J Biol Chem. 2005 Oct 21;280(42):35713-22
• All: 1 reference(s)