Trp53^tm7.1Xu
Targeted Allele Detail

Summary

• Symbol: Trp53^tm7.1Xu
• Name: transformation related protein 53; targeted mutation 7.1, Yang Xu
• MGI ID: MGI:4456121
• Synonyms: p53^R175H
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm7.1Xu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160414
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site flanked neomycin resistance gene cassette and a human gene fragment containing an amino acid substitution of arginine with histidine at position 175 (p.R175H) replaced exon 4 through 9. The neo cassette was removed by Cre-mediated recombination. (J:160414)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 232 strains or lines available

References

• Original: J:160414 Liu DP, et al., A common gain of function of p53 cancer mutants in inducing genetic instability. Oncogene. 2010 Feb 18;29(7):949-56
• All: 1 reference(s)