Rngtttm1a(KOMP)Wtsi
Targeted Allele Detail
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Symbol: |
Rngtttm1a(KOMP)Wtsi |
Name: |
RNA guanylyltransferase and 5'-phosphatase; targeted mutation 1a, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:4454082 |
Gene: |
Rngtt Location: Chr4:33310311-33502614 bp, + strand Genetic Position: Chr4, 14.78 cM
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IMPC: |
Rngtt gene page |
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Mutant Cell Lines: |
EPD0549_3_A10, EPD0549_3_A11, EPD0549_3_A12, EPD0549_3_B10, EPD0549_3_B11, EPD0549_3_B12, EPD0549_3_C10, EPD0549_3_C11, EPD0549_3_C12, EPD0549_3_D11, EPD0549_3_E11, EPD0549_3_E12, EPD0549_3_F11, EPD0549_3_F12, EPD0549_3_G11, EPD0549_3_G12, EPD0549_3_H10, EPD0549_3_H12 |
Germline Transmission: |
Unknown
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Parent Cell Line: |
JM8A3.N1 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Project Collection: |
KOMP-CSD
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Allele Type: |
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Targeted (Conditional ready, Null/knockout, Reporter) |
Mutation: |
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Insertion
Vector: L1L2_gt1
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Mutation details: The L1L2_gt1 cassette was inserted at position 33320084 of Chromosome 4 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 33320882. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele can be created by flp recombinase expression in mice carrying this allele. Subsequent cre expression results in a knockout mouse. If cre expression occurs without flp expression, a reporter knockout mouse will be created. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml
(J:148605, J:173534)
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Original: |
J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009; |
All: |
2 reference(s) |
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