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Targeted Allele Detail
Symbol: Mdktm1(KOMP)Mbp
Name: midkine; targeted mutation 1, Mouse Biology Program, UC Davis
MGI ID: MGI:4454006
Gene: Mdk  Location: Chr2:91760149-91762348 bp, - strand  Genetic Position: Chr2, 50.63 cM
Alliance: Mdktm1(KOMP)Mbp page
IMPC: Mdk gene page
Mutant Cell Lines:  DEPD00513_1_A09, DEPD00513_1_A10, DEPD00513_1_B09, DEPD00513_1_C09, DEPD00513_1_C11, DEPD00513_1_C12, DEPD00513_1_D09, DEPD00513_1_D10, DEPD00513_1_D12, DEPD00513_1_E09, DEPD00513_1_E10, DEPD00513_1_G09, DEPD00513_1_G10, DEPD00513_1_G11, DEPD00513_1_H10
Germline Transmission:  Earliest citation of germline transmission: J:188991
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: KOMP-CSD
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: L1L2_Bact_P
Mutation detailsThe insertion of the L1L2_Bact_P cassette created a deletion of size 697 starting at position 91761104 and ending at position 91761801 of Chromosome 2 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:157064)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Mdk Mutation:  23 strains or lines available
Original:  J:157064 University of California, Davis, Alleles produced for the KOMP project by the University of California, Davis. MGI Direct Data Submission. 2010;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory