Tg(NPHS2-cre/ERT2)#Mkas
Transgene Detail

Summary

• Symbol: Tg(NPHS2-cre/ERT2)#Mkas
• Name: transgene insertion, Masato Kasahara
• MGI ID: MGI:4442436
• Synonyms: NPHS2-CreER^T2
• Transgene: Tg(NPHS2-cre/ERT2)#Mkas Location: unknown
• Alliance: Tg(NPHS2-cre/ERT2)#Mkas page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(NPHS2-cre/ERT2)#Mkas expression driven by 1 gene
  Transgene expression driven by:
  

  Organism

  Driver Gene

  Homolog in Mouse

  Note

  human

  NPHS2 (7827)

  Nphs2

  (MGI:2157018)

• Mutation details: A 2.5 kb human podocin (NPHS2) promoter (from BAC clone RP11-231PS) was used to drive expression of cre recombinase fused to a mutated human estrogen receptor (cre/ERT2) in the transgenic construct. The cre/ERT2 cassette was followed by an SV40 polyA sequence. Three founders were generated. (J:159362)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	NPHS2 (human) Summary of all recombinase alleles driven by NPHS2. Comparative matrix view of recombinase activities Alliance human NPHS2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:159362 Yokoi H, et al., Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice. Nephrol Dial Transplant. 2010 Jul;25(7):2120-4
• All: 4 reference(s)