Xirp1^tm1Dofr
Targeted Allele Detail

Summary

• Symbol: Xirp1^tm1Dofr
• Name: xin actin-binding repeat containing 1; targeted mutation 1, Dieter O Furst
• MGI ID: MGI:4442410
• Synonyms: XinABC^-
• Gene: Xirp1 Location: Chr9:119842821-119852660 bp, - strand Genetic Position: Chr9, 71.36 cM
• Alliance: Xirp1^tm1Dofr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:159352
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A vector composed of an IRES element, beta-gal, and a neomycin selection cassette was inserted between the XhoI restriction site near the 5' end of exon 2 and the BamHI site near the 3' end of the same exon. Immunohistochemical analysis confirmed that all three isoforms are not expressed. (J:159352)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Xirp1 Mutation: 45 strains or lines available

References

• Original: J:159352 Otten J, et al., Complete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs. Cardiovasc Res. 2010 Mar 1;85(4):739-50
• All: 3 reference(s)