Prkra^lear-2J
Spontaneous Allele Detail

Summary

• Symbol: Prkra^lear-2J
• Name: protein kinase, interferon inducible double stranded RNA dependent activator; little ears 2 Jackson
• MGI ID: MGI:4442398
• Gene: Prkra Location: Chr2:76460242-76478359 bp, - strand Genetic Position: Chr2, 45.07 cM
• Alliance: Prkra^lear-2J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• Mutation details: These mice were discovered in a private research colony at The Jackson laboratory. The recessive lear-2J mutation results in nearly identical phenotypes to lear with mice having small body sizes, subfertility, severe hearing loss, and small ear pinnae. Due to the similarity to the lear phenotype, an allelism test was conducted and produced affected offspring, confirming that lear-2J is a second mutation in Prkra. Routine pathology screens found no obvious lesions. (J:159349)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkra Mutation: 23 strains or lines available

References

• Original: J:159349 Curtain MM, et al., An Ear Pinna Mutation in the Mouse on Chromosome Two. MGI Direct Data Submission. 2010
• All: 2 reference(s)