Tg(Emu-BCL2L1)87Nnz
Transgene Detail
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Symbol: |
Tg(Emu-BCL2L1)87Nnz |
Name: |
transgene insertion 87, Gabriel Nunez |
MGI ID: |
MGI:4441458 |
Synonyms: |
bcl-x-87 |
Transgene: |
Tg(Emu-BCL2L1)87Nnz Location: unknown
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Alliance: |
Tg(Emu-BCL2L1)87Nnz page
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Strain of Origin: |
(C57BL/6 x SJL/J)F2
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Transgene Type: |
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Transgenic (Inserted expressed sequence) |
Mutation: |
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Insertion
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Tg(Emu-BCL2L1)87Nnz expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
BCL2L1 (598) |
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Mutation details: A human BCL2L1 cDNA was cloned under the regulatory control of the SV40 promoter and the IgH enhancer (Emu). The 2.4-kb fragment containing the SV40-Emu-bcl-xL insert was microinjected into F2 hybrid zygotes from (C57BL/6 x SJL/J)F l parents. Three founder mice expressing the human cDNA BCL2L1 in lymphoid tissue, as determined by Western blot analysis, were recovered. Expression was restricted to the B-cell compartment in Line 87.
(J:31310)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:31310 Grillot DA, et al., bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J Exp Med. 1996 Feb 1;183(2):381-91 |
All: |
10 reference(s) |
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