Bid^tm1Ast
Targeted Allele Detail

Summary

• Symbol: Bid^tm1Ast
• Name: BH3 interacting domain death agonist; targeted mutation 1, Andreas Strasser
• MGI ID: MGI:4440567
• Synonyms: Bid[neo]
• Gene: Bid Location: Chr6:120870080-120894074 bp, - strand Genetic Position: Chr6, 57.02 cM
• Alliance: Bid^tm1Ast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158191
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The allele was created with a targeting vector replacing an approximately 4.5 kb region of the bid locus containing exons 1 and 2 plus part of exon 3, including the crucial BH3 domain with an loxP-flanked neoR cassette in reverse transcriptional orientation to the gene. (J:158191)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bid Mutation: 44 strains or lines available

References

• Original: J:158191 Kaufmann T, et al., The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest. Cell. 2007 Apr 20;129(2):423-33
• All: 1 reference(s)