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Nkx6-2tm2(cre)Ercs
Targeted Allele Detail
Summary
Symbol: Nkx6-2tm2(cre)Ercs
Name: NK6 homeobox 2; targeted mutation 2, Johan Ericson
MGI ID: MGI:4440471
Synonyms: Nkx6.2cre, Nkx6.2-Cre
Gene: Nkx6-2  Location: Chr7:139159292-139162713 bp, - strand  Genetic Position: Chr7, 84.57 cM
Alliance: Nkx6-2tm2(cre)Ercs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:131770
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Nkx6-2tm2(cre)Ercs expression driven by 1 gene
 
Mutation detailsThe targeting vector used to generate the Nkx6-2tm1Ercs allele was modified by replacing the lacZ/PGKneo cassette with a cre/PGKneo cassette. The same strategy as described in J:71607 was followed to generate this Nkx6-2 mutant allele using the modified targeting vector. (J:131770)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Nkx6-2 (mouse)
Summary of all recombinase alleles driven by Nkx6-2.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nkx6-2 Mutation:  17 strains or lines available
References
Original:  J:131770 Baudet C, et al., Retrograde signaling onto Ret during motor nerve terminal maturation. J Neurosci. 2008 Jan 23;28(4):963-75
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory