Tg(CAG-VCP*R155H)55Jpat
Transgene Detail

Summary

• Symbol: Tg(CAG-VCP*R155H)55Jpat
• Name: transgene insertion 55, J Paul Taylor
• MGI ID: MGI:4440439
• Synonyms: VCP-R155H
• Transgene: Tg(CAG-VCP*R155H)55Jpat Location: unknown
• Alliance: Tg(CAG-VCP*R155H)55Jpat page

Transgene origin

• Strain of Origin: SJL

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-VCP*R155H)55Jpat expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  VCP (7415)

  Vcp	(MGI:99919)

• Mutation details: The CAG promoter was used to drive ubiquitous expression of the human cDNA with nucleotide substitutions resulting in the amino acid substitution of histidine for arginine at position 155 (R155H). Five lines were created with line 55 selected as the representative line. (J:158713)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:158713 Custer SK, et al., Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone. Hum Mol Genet. 2010 May 1;19(9):1741-55
• All: 1 reference(s)