Agap2^tm1.1Kye
Targeted Allele Detail

Summary

• Symbol: Agap2^tm1.1Kye
• Name: ArfGAP with GTPase domain, ankyrin repeat and PH domain 2; targeted mutation 1.1, Keqiang Ye
• MGI ID: MGI:4439325
• Synonyms: PIKE^-
• Gene: Agap2 Location: Chr10:126911154-126929039 bp, + strand Genetic Position: Chr10, 74.5 cM
• Alliance: Agap2^tm1.1Kye page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:158376
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre mediated recombination removed exons 3 through 6. The absence of protein expression was confirmed by western blot analysis on mammary gland extracts. (J:158376)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agap2 Mutation: 48 strains or lines available

References

• Original: J:158376 Chan CB, et al., PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development. EMBO J. 2010 Mar 3;29(5):956-68
• All: 9 reference(s)