Chgb^tm1Ribo
Targeted Allele Detail

Summary

• Symbol: Chgb^tm1Ribo
• Name: chromogranin B; targeted mutation 1, Ricardo Borges
• MGI ID: MGI:4437075
• Gene: Chgb Location: Chr2:132623562-132636999 bp, + strand Genetic Position: Chr2, 64.74 cM, cytoband F-G
• Alliance: Chgb^tm1Ribo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157697
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: 117 bases of the proximal promoter region and first 29 bases of the coding region are replaced with a targeting vector. The absence of protein expression was confirmed by immunohistochemistry on adrenal glands. (J:157614, J:157697)

Generation of the Chgb^tm1Ribo allele

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chgb Mutation: 23 strains or lines available

References

• Original: J:157697 Diaz-Vera J, et al., Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles. J Neurosci. 2010 Jan 20;30(3):950-7
• All: 6 reference(s)