Pax7^{tm1(cre/Esr1*)Cklr}
Targeted Allele Detail

Summary

• Symbol: Pax7^{tm1(cre/Esr1*)Cklr}
• Name: paired box 7; targeted mutation 1, Charles Keller
• MGI ID: MGI:4436914
• Synonyms: Pax7^CreER, Pax7-CreER, Pax7^CreERp, Pax7-CreER^tm
• Gene: Pax7 Location: Chr4:139464373-139560839 bp, - strand Genetic Position: Chr4, 70.83 cM
• Alliance: Pax7^{tm1(cre/Esr1*)Cklr} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157754
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Pax7^{tm1(cre/Esr1*)Cklr} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Pax7 (MGI:97491)

• Mutation details: Homologous recombination in ES cells inserted an IRES-creER^TM-FRT-Neo-FRT sequence into the 3' UTR following the stop codon in exon 9. (J:157754)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax7 (mouse) Summary of all recombinase alleles driven by Pax7. Comparative matrix view of recombinase activities Alliance mouse Pax7 gene page

Tumor Data

List all tumor models in MMHCdb carrying Pax7^{tm1(cre/Esr1*)Cklr}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pax7 Mutation: 39 strains or lines available

References

• Original: J:157754 Nishijo K, et al., Biomarker system for studying muscle, stem cells, and cancer in vivo. FASEB J. 2009 Aug;23(8):2681-90
• All: 51 reference(s)