Gsta3^tm1Sell
Targeted Allele Detail

Summary

• Symbol: Gsta3^tm1Sell
• Name: glutathione S-transferase, alpha 3; targeted mutation 1, Stewart Sell
• MGI ID: MGI:4430389
• Gene: Gsta3 Location: Chr1:21310789-21335799 bp, + strand Genetic Position: Chr1, 6.5 cM
• Alliance: Gsta3^tm1Sell page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:157029
• Parent Cell Line: C57BL/6J-693 (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted by homologous recombination replacing exons 3-6. Absence of RNA expression in the liver and kidneys was confirmed by RT-PCR analysis. Absence of protein was confirmed by western blot of liver extracts. (J:157029)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gsta3 Mutation: 36 strains or lines available

Notes

ES cell line = C57BL/6J-693 (ATCC #SCRC-1002).

References

• Original: J:157029 Ilic Z, et al., Glutathione-S-transferase A3 knockout mice are sensitive to acute cytotoxic and genotoxic effects of aflatoxin B1. Toxicol Appl Pharmacol. 2010 Feb 1;242(3):241-6
• All: 4 reference(s)