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Slc26a7tm1Sole
Targeted Allele Detail
Summary
Symbol: Slc26a7tm1Sole
Name: solute carrier family 26, member 7; targeted mutation 1, Manoocher Soleimani
MGI ID: MGI:4429559
Gene: Slc26a7  Location: Chr4:14502430-14621805 bp, - strand  Genetic Position: Chr4, 6.24 cM
Alliance: Slc26a7tm1Sole page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:156969
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4 were replaced by a neomycin selection cassette. These exons encode 168 amino acids. Northern blot analysis confirmed the absence of mRNA and the absence of protein was established immunologically. (J:156969)
Generation of the Slc26a7tm1Sole allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc26a7 Mutation:  50 strains or lines available
References
Original:  J:156969 Xu J, et al., Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem. 2009 Oct 23;284(43):29470-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory