Grn^tm1Aidi
Targeted Allele Detail

Summary

• Symbol: Grn^tm1Aidi
• Name: granulin; targeted mutation 1, Aihao Ding
• MGI ID: MGI:4421704
• Synonyms: pgrn^flox
• Gene: Grn Location: Chr11:102321333-102327635 bp, + strand Genetic Position: Chr11, 66.29 cM
• Alliance: Grn^tm1Aidi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:156824
• Parent Cell Line: C2J (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J/J

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1 and an frt floxed neo cassette with a 3' loxP site was inserted downstream of exon 4. (J:156824)

Generation of the Grn^tm1Aidi and Grn^tm1.1Aidi alleles

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Grn Mutation: 44 strains or lines available

References

• Original: J:156824 Yin F, et al., Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010 Jan 18;207(1):117-28, S1-4
• All: 3 reference(s)