Dmrt3^tm1Hgc
Targeted Allele Detail

Summary

• Symbol: Dmrt3^tm1Hgc
• Name: doublesex and mab-3 related transcription factor 3; targeted mutation 1, Edward M Rubin
• MGI ID: MGI:4420993
• Gene: Dmrt3 Location: Chr19:25587665-25601285 bp, + strand Genetic Position: Chr19, 20.5 cM
• Alliance: Dmrt3^tm1Hgc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:128347
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The mutant allele was generated by deleting a sequence covering exon 1, which includes the start codon and the DM binding domain of the encoded protein. A loxP-flanked neomycin selection cassette replaced a part of exon 1, and the cassette was subsequently removed via cre-mediated recombination. (J:187218)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dmrt3 Mutation: 12 strains or lines available

References

• Original: J:128347 Ahituv N, et al., Deletion of ultraconserved elements yields viable mice. PLoS Biol. 2007 Sep;5(9):e234
• All: 2 reference(s)