Aldoa^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Aldoa^{tm1(KOMP)Wtsi}
• Name: aldolase A, fructose-bisphosphate; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419797
• Gene: Aldoa Location: Chr7:126394406-126399537 bp, - strand Genetic Position: Chr7, 69.25 cM, cytoband F4
• Alliance: Aldoa^{tm1(KOMP)Wtsi} page
• IMPC: Aldoa gene page

Mutation origin

• Mutant Cell Lines: EPD0407_5_A02, EPD0407_5_A03, EPD0407_5_B03, EPD0407_5_B04, EPD0407_5_C03, EPD0407_5_C04, EPD0407_5_D03, EPD0407_5_D04, EPD0407_5_E01, EPD0407_5_E02, EPD0407_5_E03, EPD0407_5_E04, EPD0407_5_F02, EPD0407_5_F04, EPD0407_5_G01, EPD0407_5_G03, EPD0407_5_G04, EPD0407_5_H01, EPD0407_5_H03, EPD0407_5_H04
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A1.N3 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 1893 starting at position 126395087 and ending at position 126396980 of Chromosome 7 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Aldoa Mutation: 28 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 3 reference(s)