Plod3^{tm1(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Plod3^{tm1(KOMP)Wtsi}
• Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:4419668
• Gene: Plod3 Location: Chr5:137015873-137025500 bp, + strand Genetic Position: Chr5, 76.09 cM
• Alliance: Plod3^{tm1(KOMP)Wtsi} page
• IMPC: Plod3 gene page

Mutation origin

• Mutant Cell Lines: EPD0385_3_B11, EPD0385_3_C09, EPD0385_3_C10, EPD0385_3_C12, EPD0385_3_D09, EPD0385_3_E12, EPD0385_3_F09, EPD0385_3_F11, EPD0385_3_G10, EPD0385_3_G12, EPD0385_3_H10, EPD0385_3_H11
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_Bact_P
• Mutation details: The insertion of the L1L2_Bact_P cassette created a deletion of size 3327 starting at position 137017424 and ending at position 137020751 of Chromosome 5 (Genome Build GRCm39). This deletion results in the removal of functionally critical exon(s). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. (J:148605, J:173534)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Plod3 Mutation: 61 strains or lines available

References

• Original: J:148605 Wellcome Trust Sanger Institute, Alleles produced for the KOMP project by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2009
• All: 3 reference(s)